Three big money debuts marked the box office this weekend. Animated film Megamind took the top spot, earning $47.6 million. It easily handled the antics of Zach Galifiankis and Robert Downey, Jr. in their comedy debut Due Date. That film earned an impressive $33.5 million in second position.

Tyler Perry‘s For Colored Girls opened to the tune of $20.1 million to finish third on the weekend, reiterating that Perry is always good for a decent box office showing.

Farther down the list, Secretariat battled Zenyatta for horse-racing supremacy. The former earned $4 million in its 5th week, totaling $51 million, while the latter lost for the first time in her career in her last race at Churchill Downs.

Oscar contender 127 Hours opened in 4 theaters, earning $266,000 total (averaging $66,500). Expect big earnings here when it expands its release.

Next week sees the opening of news comedy Morning Glory on Wednesday, and a pair of thrillers in Skyline and Unstoppable. I expect Denzel Washington‘s strong fan base to carry Unstoppable to the top spot in the box office.

Check out this week’s top 10 (movie- weekend; total):

1. Megamind– $47,650,000; $47,650,000 (debut)

2. Due Date– $33,500,000; $33,500;000 (debut)

3. For Colored Girls– $20,100,000; $20,100,000 (debut)

4. Red– $8,858,000; $71,871,000

5. Saw 3D– $8,200,000; $38,801,000

6. Paranormal Activity 2– $7,298,000; $77,224,000

7. Jackass 3-D– $5,097,000; $110,814,000

8. Hereafter– $4,020,000; $28,730,000

9. Secretariat- $4,002,000; $50,965,000

10. The Social Network– $3,600,000; $85,047,000

Which of these is your favorite? What will you see next weekend?

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